Quarterback
Biggest Winner: Trevor Lawrence (Jaguars)
It was quite the QB duel in London between C.J Stroud and Lawrence on Sunday and while the Texans ultimately won the game on a Ka'imi Fairbairn field goal at the end of regulation, Lawrence (306 YDS, 4 TD's, INT, 11 Rushing YDS) proved to be the top dog in fantasy. The Jaguars franchise quarterback has been an up-and-down QB1 play through 6 weeks, and his owners will be hoping for a little more consistency after his Week 7 bye.
Honorable Mentions: Tyler Shough (Saints), Drake Maye (Patriots), C.J. Stroud (Texans)
Biggest Loser: Patrick Mahomes (Chiefs)
Mahomes had a largely uneventful showing against the completely aloof and defeated Chargers, throwing for 272 scoreless YDS, an INT and picking up 16 YDS on the ground as the Chiefs cruised to victory. He'll be a questionable starting option for this week's tough road game in Seattle.
Dishonorable Mentions: Dak Prescott (Cowboys), Matthew Stafford (Rams), Brock Purdy (49ers)
Running Back
Biggest Winner: Kenneth Walker III (Chiefs)
In a shocking development coming off the bye, The Chiefs offense once again ran through Walker. Their big free agent pickup needed just 21 touches (19 carries, 2 receptions) to hang 139 scrimmage YDS and 2 rushing TD's on the Chargers abysmal defense. Walker has been unstoppable to start 2026 and his old friends on the Seahawks are going to have put together one hell of showing in order to become the first defense this season to slow him down.
Honorable Mentions: James Cook (Bills), Bhayshul Tuten (Jaguars), D'Andre Swift (Bears)
Biggest Loser: Derrick Henry (Ravens)
The Browns defense took advantage of the Ravens banged-up offensive line and Tyler Huntley's presence under center and completely stifled Henry-holding him to 58 YDS on 17 carries and forcing him to lose a huge fumble in the 4th quarter that led to the only TD they scored in their 13-10 upset victory. Henry's weekly YPC hasn't exceeded 4.3 YDS since his Week 1 eruption over the Colts, and he could have a tough time returning to his top form this week against a Bengals defense that has been pretty stingy thus far.
Dishonorable Mentions: Bijan Robinson (Falcons), Bucky Irving (Buccaneers), Rhamondre Stevenson (Patriots)
Wide Receiver
Biggest Winner: Tre Tucker (Raiders)
One of this week's top wire targets delivered in a big way, torching the Bills poor secondary for 97 YDS and 2 TD's on 5 receptions. While it's unlikely that he'll turn into a weekly starting option with Brock Bowers gobbling up so many targets from Kirk Cousins, Tucker's status as the Raiders de facto WR1 and explosive play ability should be enough to keep him rostered in most leagues moving forward.
Honorable Mentions: Malik Nabers (Giants), Germie Bernard (Steelers), Matthew Golden (Packers)
Biggest Loser: A.J. Brown (Patriots)
It was an ugly return to action for Brown, who was activated from IR on Saturday morning after missing 4 games with a high ankle sprain. The Patriots wideout dropped 5 (!) passes and showed an alarming lack of chemistry with Drake Maye as he finished with just 3 catches for 27 YDS in a win over the Jets. Until Brown shows some form of life with his new team, he should be riding the bench in all leagues that have 12 teams or less.
Dishonorable Mentions: Jaylen Waddle (Broncos), Michael Wilson (Cardinals), Denzel Boston (Browns)
Tight End
Biggest Winner: Isaiah Likely (Giants)
An in-game QB change didn't impact Likely in the slightest as negative gamescript caused the Giants to throw the ball like crazy in the second half as they attempted to (and just fell short) off pulling a crazy comeback win over the Saints. While Malik Nabers was the top dog in both receptions and YDS, Likely found the endzone, was on the receiving end of a 2 PT-CNV and turned his 6 receptions into an excellent 99 YDS. Whether it's Jameis Winston or J.J. McCarthy under center for the Giants on Sunday against the Texans, Likely will remain a must-start TE1.
Honorable Mentions: Kyle Pitts (Falcons), Colston Loveland (Bears), George Kittle (49ers)
Biggest Loser: Juwan Johnson (Saints)
It was an odd day for the Saints offense as Tyler Shough threw for 3 TD's but only completed 15 passes for 144 YDS and turned to their running game down the stretch as they jumped out to a 34-10 lead with 11:31 left in the game. This unique situation left Johnson completely out in the cold as he failed to catch either of the targets that came his way and put together his 2nd straight dud after being a top fantasy TE through the opening 4 weeks of the season. Johnson will look to return to fantasy relevancy in Week 7 when the Saints travel over to Paris to take on the Steelers.
Dishonorable Mentions: Harold Fannin Jr. (Browns), Mark Andrews (Ravens), Jake Ferguson (Cowboys)
Defense/Special Teams
Biggest Winner: Chiefs
The Chargers anemic offense got completely picked apart by Steve Spagnuolo on Sunday, registering 4 sacks, an INT and fumble recovery in a commanding 22-6 win for the still undefeated Chiefs. This strong fantasy D/ST has another plus matchup in Week 7 against a Seahawks team that has struggled with allowing sacks and giveaways of late.
Honorable Mentions: Broncos, Steelers, Ravens
Biggest Loser: Texans
As you can safely assume, the aforementioned great play of C.J. Stroud and Trevor Lawrence were coupled with dismal showings from their respective defenses. Despite them being good enough on the last drive to help secure the win, Lawrence's status as the top fantasy QB made the Texans a slightly weaker option. They were held without a sack for the 1st time this season and a redzone INT by Calen Bullock proved to be their lone fantasy highlight in the 34-31 victory. A return to the top of the board is very much in play in Week 7 as they face a Giants team that has turned the ball over an absurd 9 times in their past 3 games.
Dishonorable Mentions: Jaguars, Rams, Seahawks