Week 10 Fantasy Football Winners and Losers

Quarterback
MVP: Drew Brees (Saints)
Drew Brees's performance on Sunday was even insane by his standards. Brees looked like a man possessed completing 83% of his passes for 392 yards and 4 TD's in the Saints 49-17 beatdown of the Cowboys on Sunday night. Brees has been the most consistent QB1 this season not named Peyton Manning and I'm sure he'll continue to make his owners happy for the rest of the season.
Honorable Mentions: Robert Griffin III (Redskins), Peyton Manning (Broncos), Nick Foles (Eagles), Russell Wilson (Seahawks)

LVP: Philip Rivers (Chargers)
Philip Rivers didn't play too bad against the Broncos on Sunday putting up 216 yards and a touchdown. That being said, everyone expected more with Rivers on a hot streak and a Broncos secondary that has allowed a ton of fantasy points to quarterbacks all season long.
Dishonorable Mentions: Andrew Luck (Colts), Eli Manning (Giants), Colin Kaepernick (49ers), Cam Newton (Panthers)

Running Back
MVP: Pierre Thomas (Saints)
No you are not imagining things, a Saints running back was the most valuable fantasy running back this week. The Saints managed to run all over the Cowboys all game long with Pierre Thomas putting up the most impressive numbers with 111 total yards and 2 TD's (1 rushing, 1 receiving) I wouldn't get too excited for the Saints rushing game to make a resurgence though. They play some really tough run defenses (49ers, Seahawks, Panthers twice) down the stretch and it can not be stressed enough how bad this team is at running at the ball most weeks.
Honorable Mentions: Marshawn Lynch (Seahawks), Adrian Peterson (Vikings), Darren Sproles (Saints), Andre Brown (Giants)

LVP: Chris Johnson (Titans)
A week after C2J returned to vintage form against the Rams, he reverted right back to the new, lackluster C2J. He somehow managed to only gain 30 yards (2.5 yards per carry) on the league-worst rushing defense of the Jaguars. Johnson continues to disappoint and despite a few strong moments, can't develop any momentum this season. Johnson is a low-end RB2 moving forward and continues to show he can not trusted to perform consistently.
Dishonorable Mentions: C.J. Spiller (Bills), Matt Forte (Bears), Eddie Lacy (Packers), Fred Jackson (Bills)

Wide Receiver
MVP: Demaryius Thomas (Broncos)
Good ol' Demaryius "Bay Bay" Thomas was Peyton Manning's weapon of choice this week. 3 of his 7 receptions were touchdowns and pretty much carried the team to victory over the Chargers on a slow day for most of the Broncos receiving corps.
Honorable Mentions: A.J. Green (Bengals), Tavon Austin (Rams), Brandon Marshall (Bears), Riley Cooper (Eagles)

LVP: Wes Welker (Broncos)
The normally effective Wes Welker was held to a measly 21 yards against the Chargers weak secondary on Sunday. Demaryius and Julius Thomas got all the attention from Manning, leaving Welker and Eric Decker to put up poor numbers. This performance shouldn't be much to fret for Welker owners though. This offense is absolutely loaded with talent and Welker will get more than his fair share of opportunities to shine the rest of this season.
Dishonorable Mentions: Victor Cruz (Giants), Keenan Allen (Chargers), Eric Decker (Broncos), Dez Bryant (Cowboys)

Tight End
MVP: Julius Thomas (Broncos)
Julius Thomas did most of his damage on a 74-yard touchdown catch in the 1st quarter, but in a week where most tight ends disappointed, it was more than enough to make him the best fantasy play of the week.
Honorable Mentions: Jordan Reed (Redskins), Delanie Walker (Titans), Brandon Pettigrew (Lions), Antonio Gates (Chargers)

LVP: Jimmy Graham (Saints)
For a normal tight end, 59 yards in a game would be a perfectly fine game. For Jimmy Graham, it's an off-game. Graham's numbers are especially disappointing considering that the Saints had a field day with the Cowboys defense on Sunday night. In Graham's defense, he is playing hurt, but for such a dominant player like Graham to not put up double-digit fantasy points is a big letdown.
Dishonorable Mentions: Greg Olsen (Panthers), Martellus Bennett (Bears), Garrett Graham (Texans), Vernon Davis (49ers)

Defense
MVP: St. Louis Rams
The up-and-down Rams defense put up one of their most dominant performances of the season in their surprising blowout victory over the Colts. The defense gave Andrew Luck and co. hell with 5 takeaways, 3 sacks and a defensive touchdown on the afternoon.  
Honorable Mentions: New York Giants, Oakland Raiders, Carolina Panthers, Arizona Cardinals

LVP: Tennessee Titans
Sunday was not kind to the Titans, who gave the Jaguars their first victory of the season. The defense was a big part of that managing only 3 sacks and 2 takeaways against a team that has been very generous to fantasy defenses all season long.
Dishonorable Mentions: Indianapolis Colts, Buffalo Bills, Green Bay Packers, Miami Dolphins