Quarterback
Biggest Winner: Dak Prescott (Cowboys)
Prescott didn't have to work too hard to dismantle the Jets horrendous defense on Sunday afternoon, throwing for 237 YDS and 4 TD's and rushing for 28 YDS on 7 carries. The Cowboys QB has returned to the elite QB1 form he showed in 2023 and could be in line to feast for a 4th straight game against the Panthers in Week 6.
Honorable Mentions: Patrick Mahomes (Chiefs), Baker Mayfield (Buccaneers), Justin Fields (Jets)
Biggest Loser: Drake Maye (Patriots)
There's no better example of the disconnect between the real game and fantasy football than Maye ending up in this slot after leading the Patriots to an upset win over the Bills that is being hailed as his brightest moment in the pros to date thanks to being held to 285 scoreless YDS (273 passing, 12 rushing). A return to the endzone (and fantasy relevance) feels very likely when the Pats take on the frisky but not overly talented Saints in Week 6.
Dishonorable Mentions: Justin Herbert (Chargers), Kyler Murray (Cardinals), Daniel Jones (Colts)
Running Back
Biggest Winner: Rico Dowdle (Panthers)
Stepping in for the injured Chuba Hubbard, Dowdle absolutely obliterated the Dolphins porous run defense for a whopping 206 YDS and a TD on 23 carries. He added another 28 YDS on 3 receptions to pad what will surely go down as one of the most ludicrous statlines of the 2025 season. What his role will be once Hubbard returns remains unclear right now, but one thing is for sure: the people who picked up Dowdle in an act of sheer desperation late last week entered a state of unexpected euphoria on Sunday and this humble act of public service is something that nobody will ever be able to take away from him.
Honorable Mentions: Jonathan Taylor (Colts), Kyren Williams (Rams), Javonte Williams (Cowboys)
Biggest Loser: James Cook (Bills)
One of the biggest reasons the Patriots were able to come out of Orchard Park with the win on Sunday was their success in neutralizing Cook. The Bills versatile backfield weapon was blanked in the passing game and picked up just 49 YDS on 15 carries on a night where a splash play or two from him could've flipped the outcome of this divisional rockfight. Cook has a date with the Falcons in Week 6.
Dishonorable Mentions: TrVeyon Henderson (Patriots), Woody Marks (Texans), R.J. Harvey (Broncos)
Wide Receiver
Biggest Winner: Emeka Egbuka (Buccaneers)
Egbuka cleared his previous career high once again with a dominant performance (7/163/1, 1 2 PT-CNV) that helped the Bucs eke out a win in an electrifying shootout with the Seahawks. The concerns about his target share being cut once Mike Evans returns from his hamstring injury are decreasing with each passing day as the rookie continues to deliver week after week. Egbuka will be a WR1/2 play for this week's contest with the 49ers.
Honorable Mentions: Ja'Marr Chase (Bengals), Jaxson Smith-Njiba (Seahawks), Jaylen Waddle (Dolphins)
Biggest Loser: Jameson Williams (Lions)
Williams simply never got involved in the Lions win over the Bengals, catching his lone target for 9 YDS and gaining 1 YD on 1 carry. No need to panic just yet as the splash play specialist is suspectable to duds like this from time to time. Williams should be a solid WR3 option for their big time Week 6 SNF showdown with the Chiefs.
Dishonorable Mentions: Jerry Jeudy (Browns), Quentin Johnston (Chargers), Jakobi Meyers (Raiders)
Tight End
Biggest Winner: Jake Ferguson (Cowboys)
Ferguson was very active in the Cowboys breeze of a win over the Jets, catching 7 passes for 49 YDS and a pair of TD's. The veteran tight end should remain a focal point of their passing attack as long as CeeDee Lamb remains on the shelf with a high ankle sprain.
Honorable Mentions: Sam LaPorta (Lions), Darren Waller (Dolphins), Sam LaPorta (Lions)
Biggest Loser: Zach Ertz (Commanders)
The return of Jayden Daniels and continued absence of Terry McLaurin didn't help Ertz at all as he failed to catch his lone target and ended up with the dreaded goose egg against the Chargers. Ertz faces the Bears poor, injury-depleted defense in Week 6.
Dishonorable Mentions: Juwan Johnson (Saints), Mark Andrews (Ravens), Trey McBride (Cardinals)
Defense/Special Teams:
Biggest Winner: Colts
The Raiders floundering offense and special teams had another rough showing this week, surrendering 4 sacks, 2 INT and a blocked punt to the Colts in a deflating 40-6 loss in Indy. The Colts D/ST has been one of the biggest pleasant surprises of the opening stretch in 2025 and deserve to be rostered in all leagues right now.
Honorable Mentions: Texans, Lions, Cardinals
Biggest Loser: Vikings
While it wasn't an awful showing by any stretch, you'd just expect a Brian Flores defense to cause more problems for a rookie QB (Dillon Gabriel) making his first career start than sacking him twice and forcing 0 turnovers in a 21-17 win. The Vikings could be a shaky start when they return to action in Week 7 versus the Eagles.
Dishonorable Mentions: Eagles, Ravens, Seahawks
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